Mechanisms controlling gene expression in Yersinia enterocolitica at the transcriptional level – role of EnvZ/OmpR, two-component signal transduction system

Principal Investigators: Katarzyna Brzostek

Our previous studies have demonstrated, that OmpR, the response regulator of two component transduction system EnvZ/OmpR, participates in the pathophysiology of Yersinia enterocolitica. By acting as a global regulator of gene expression, including virulence genes, OmpR produces pleiotropic effects in this enteropathogen. OmpR is involved in the adaptation of this pathogen to multiple environmental stresses by controlling of various cellular processes and functions, including adhesion, invasion, motility, Yop production, biofilm formation, and multidrug and serum resistance. 

Our current research focuses on the contribution of OmpR to iron homeostasis in Y. enterocolitica. We will establish whether there exists direct OmpR-dependent regulation of fur transcription and consequently whether or not OmpR controls expression of selected Fur regulon members.

Besides expanding the knowledge base concerning OmpR, our research highlight TCSs as potential targets for inhibitors that might be used therapeutically to fight bacterial infections in this era of widespread antibiotic resistance.

FUNDING SOURCES: Opus 11 grant, National Science Centre, Poland